Scientific Name: Zileuton
Brand Name: Zyflo
Company Owner: Cornerstone therapeutics inc
Mechanism Of Action Leukotrienes are substances that induce numerous biological effects including augmentation of neutrophil and eosinophil migration, neutrophil and monocyte aggregation, leukocyte adhesion, increased capillary permeability, and smooth muscle contraction. These effects contribute to inflammation, edema, mucus secretion, and bronchoconstriction in the airways of asthmatic patients. Zileuton relieves such symptoms through its selective inhibition of 5-lipoxygenase, the enzyme that catalyzes the formation of leukotrienes from arachidonic acid. Specifically, it inhibits leukotriene LTB4, LTC4, LTD4, and LTE4 formation. Both the R(+) and S(-) enantiomers are pharmacologically active as 5-lipoxygenase inhibitors in
Description of the Drug: Zileuton is a leukotriene synthesis inhibitor used in the prophylaxis and treatment of chronic asthma.
Protein Data Bank: Not Available
Source: DrugBank Online – Retrieved 2023-01-23 from