Zalcitabine

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Scientific Name: Zalcitabine
Brand Name: Not Available
Company Owner: Hoffmann la roche inc
Mechanism Of Action Zalcitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1) . Within cells, zalcitabine is converted to its active metabolite, dideoxycytidine 5′-triphosphate (ddCTP) , by the sequential action of cellular enzymes. ddCTP interferes with viral RNA-directed DNA polymerase (reverse transcriptase) by competing for utilization of the natural substrate deoxycytidine 5′-triphosphate (dCTP) , as well as incorpating into viral DNA. Due to it’s lack of a 3′-OH group, the formation of a 5′ to 3′ phosphodiester linkage that is necessary for DNA chain elongation is inhibited, thus leading to the termination of viral DNA growth.
Description of the Drug: Zalcitabine is a dideoxynucleoside used to treat HIV.
Protein Data Bank: Not Available
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB00943