Tolbutamide
Back to search| Scientific Name: | Tolbutamide |
| Brand Name: | Not Available |
| Company Owner: | Not Available |
| Mechanism Of Action | Sulfonylureas lower blood glucose in patients with NIDDM by directly stimulating the acute release of insulin from functioning beta cells of pancreatic islet tissue by an unknown process that involves a sulfonylurea receptor (receptor 1) on the beta cell. Sulfonylureas inhibit the ATP-potassium channels on the beta cell membrane and potassium efflux, which results in depolarization and calcium influx, calcium-calmodulin binding, kinase activation, and release of insulin-containing granules by exocytosis, an effect similar to that of glucose. |
| Description of the Drug: | Tolbutamide is a sulfonylurea used to treat hyperglycemia in patients with type 2 diabetes mellitus. |
| Protein Data Bank: | Not Available |
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB01124
