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Scientific Name: Thiethylperazine
Brand Name: Not Available
Company Owner: Novartis pharmaceuticals corp
Mechanism Of Action Thiethylperazine is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1) -receptors, and histamine H1-receptors. Thiethylperazine’s antipsychotic effect is due to antagonism at dopamine and serotonin type 2 receptors, with greater activity at serotonin 5-HT2 receptors than at dopamine type-2 receptors. This may explain the lack of extrapyramidal effects. Thiethylperazine does not appear to block dopamine within the tubero-infundibular tract, explaining the lower incidence of hyperprolactinemia than with typical antipsychotic agents or risperidone. Antagonism at muscarinic receptors, H1-receptors, and alpha(1) -receptors also occurs with thiethylperazine.
Description of the Drug: Thiethylperazine is a drug used for the treatment of nausea and vomiting.
Protein Data Bank: Not Available
Source: DrugBank Online – Retrieved 2023-01-23 from