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Scientific Name: Theophylline
Brand Name: Elixophyllin, Elixophylline, Pulmophylline, Quibron-T, Theo-24, Theolair, Uniphyl
Company Owner: Fleming and co pharmaceuticals inc, Forest laboratories inc, Sanofi aventis us llc, Dm graham laboratories inc, Ucb inc, Whitby pharmaceuticals inc, Schwarz pharma inc, Schering corp, Central pharmaceuticals inc, Hospira inc, Inwood laboratories inc sub forest laboratories inc, Sandoz inc, Rp scherer north america div rp scherer corp, Ortho mcneil pharmaceutical inc, Schering corp sub schering plough corp, Fisons corp, Kv pharmaceutical co, Rp scherer north america, Hr cenci laboratories inc, Caraco pharmaceutical laboratories ltd, Lannett co inc, Panray corp sub ormont drug and chemical co inc, Alpharma us pharmaceuticals division, Cenci powder products inc, Halsey drug co inc, L perrigo co, Pharmaceutical assoc inc div beach products, Precision dose inc, Roxane laboratories inc, Taro pharmaceuticals usa inc, Wockhardt eu operations (swiss) ag, B braun medical inc, Baxter healthcare corp, 3m pharmaceuticals inc, Ferndale laboratories inc, Warner chilcott co llc, Monarch pharmaceuticals inc, Roerig div pfizer inc, Able laboratories inc, Glenmark generics ltd, Nostrum pharmaceuticals inc, Pliva inc, Pharmaceutical research assoc inc, Purdue pharmaceutical products lp, Graceway pharmaceuticals llc, Novartis consumer health inc
Mechanism Of Action Theophylline relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels and reduces airway responsiveness to histamine, methacholine, adenosine, and allergen. Theophylline competitively inhibits type III and type IV phosphodiesterase (PDE) , the enzyme responsible for breaking down cyclic AMP in smooth muscle cells, possibly resulting in bronchodilation. Theophylline also binds to the adenosine A2B receptor and blocks adenosine mediated bronchoconstriction. In inflammatory states, theophylline activates histone deacetylase to prevent transcription of inflammatory genes that require the acetylation of histones for transcription to begin.
Description of the Drug: Theophylline is a xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction.
Protein Data Bank:
Source: DrugBank Online – Retrieved 2023-01-23 from