Isosorbide dinitrate

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Scientific Name: Isosorbide dinitrate
Brand Name: Bidil, Dilatrate, Isordil
Company Owner: Alcon laboratories inc, Schwarz pharma inc, Wyeth ayerst laboratories, Astrazeneca pharmaceuticals lp, Caraco pharmaceutical laboratories ltd, Corepharma llc, Biovail laboratories inc, Mutual pharmaceutical co inc, Par pharmaceutical inc, Sandoz inc, Superpharm corp, Watson laboratories inc, West ward pharmaceutical corp, West ward inc
Mechanism Of Action Isosorbide dinitrate is converted to the active nitric oxide to activate guanylate cyclase. This activation increases levels of cyclic guanosine 3′, 5′-monophosphate (cGMP) . cGMP activates protein kinases and causes a series of phosphorylation reactions which leads to dephosphorylation of myosin light chains of smooth muscle fibres. Finally there is a release of calcium ions which causes smooth muscle relaxation and vasodilation.
Description of the Drug: Isosorbide dinitrate is a vasodilator used to treat angina in coronary artery disease.
Protein Data Bank: Not Available
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB00883