Estramustine

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Scientific Name: Estramustine
Brand Name: Emcyt
Company Owner: Not Available
Mechanism Of Action Estramustine is a derivative of estradiol with a nitrogen mustard moiety. This gives it alkylating properties. In vivo, the nitrogen mustard component is active and can alklyate DNA and other cellular components (such as tubulin components) of rapidly dividing cells. This causes DNA strandbreaks or misscoding events. This leads to apoptosis and cell death. Also, due to the drugs estrogen component, it can bind more selectively to active estrogen receptors.
Description of the Drug: Estramustine is an antineoplastic agent used for the management of metastatic and/or progressive prostate cancer in palliative setting.
Protein Data Bank: Not Available
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB01196