Deferoxamine

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Scientific Name: Deferoxamine
Brand Name: Desferal
Company Owner: App pharmaceuticals llc, Bedford laboratories div ben venue laboratories inc, Hospira inc, Watson laboratories inc, Novartis pharmaceuticals corp
Mechanism Of Action Deferoxamine works in treating iron toxicity by binding trivalent (ferric) iron (for which it has a strong affinity) , forming ferrioxamine, a stable complex which is eliminated via the kidneys. 100 mg of deferoxamine is capable of binding approximately 8.5 mg of trivalent (ferric) iron. Deferoxamine works in treating aluminum toxicity by binding to tissue-bound aluminum to form aluminoxamine, a stable, water-soluble complex. The formation of aluminoxamine increases blood concentrations of aluminum, resulting in an increased concentration gradient between the blood and dialysate, boosting the removal of aluminum during dialysis. 100 mg of deferoxamine is capable of binding approximately 4.1 mg of aluminum.
Description of the Drug: Deferoxamine is a chelating agent used to treat iron or aluminum toxicity and some blood transfusion dependent anemias.
Protein Data Bank:
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB00746