Crisaborole
Back to search| Scientific Name: | Crisaborole |
| Brand Name: | Eucrisa |
| Company Owner: | Not Available |
| Mechanism Of Action | Inhibition of PDE4 by crisaborole leads to elevated levels of cyclic adenosine monophosphate (cAMP) . Increased intracellular levels of cAMP inhibit the NF-kB pathway and suppress the release of pro-inflammatory mediators such as TNF-alfa and various interleukins that play a causative role in psoriasis and atopic dermatitis. Suppression of downstream effects in different cell types may explain the therapeutic role of crisaborole in immune-mediated skin diseases. |
| Description of the Drug: | Crisaborole is a non-steroidal topical medication used for the treatment of mild-moderate atopic dermatitis. |
| Protein Data Bank: | Not Available |
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB05219
