Crisaborole

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Scientific Name: Crisaborole
Brand Name: Eucrisa
Company Owner: Not Available
Mechanism Of Action Inhibition of PDE4 by crisaborole leads to elevated levels of cyclic adenosine monophosphate (cAMP) . Increased intracellular levels of cAMP inhibit the NF-kB pathway and suppress the release of pro-inflammatory mediators such as TNF-alfa and various interleukins that play a causative role in psoriasis and atopic dermatitis. Suppression of downstream effects in different cell types may explain the therapeutic role of crisaborole in immune-mediated skin diseases.
Description of the Drug: Crisaborole is a non-steroidal topical medication used for the treatment of mild-moderate atopic dermatitis.
Protein Data Bank: Not Available
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB05219