Scientific Name: Alvimopan
Brand Name: Entereg
Company Owner: Not Available
Mechanism Of Action Alvimopan competitively binds to mu-opioid receptor in the gastrointestinal tract but, unlike methylnaltrexone which relies upon it ionic charge, alvimopan owes its selectivity for peripheral receptors to its pharmacokinetics. Alvimopan binds to peripheral mu-receptors with a Ki of 0.2 ng/mL.
Description of the Drug: Alvimopan is an opioid antagonist used to reduce healing time of the upper and lower gastrointestinal tract following surgical procedures that involve bowel resection with primary anastomosis.
Protein Data Bank:
Source: DrugBank Online – Retrieved 2023-01-23 from