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- Cytokine Release Syndrome (CRS)
- Data and Safety Monitoring Board (DSMB)
- Data and Safety Monitoring Plan (DSMP)
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- Data Management Plan (DMP)
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What is ctDNA? Circulating tumor DNA (ctDNA) is cell free DNA- dsDNA and mtDNA- from tumor cells that can be found in the plasma of cancer patients.
What is ctDNA used for?
ctDNA has growing applications as liquid or blood biopsies for:
- Evaluating mutations in tumor cells.
- Monitoring response to treatment.
- Monitoring changes to the tumor as the half-life of ctDNA is from 30 minutes to two hours.
- Use as a surrogate to assess tumor stage, size, and aggressiveness, based on the concentration of the ct DNA and the number of somatic changes.
- Possible advancements in cancer screening.
- Companion diagnostics
- Identification of possible treatment targets
Source: Adashek, J. J., Janku, F., & Kurzrock, R. (2021). Signed in Blood: Circulating Tumor DNA in Cancer Diagnosis, Treatment and Screening. Cancers, 13(14), 3600. https://doi.org/10.3390/cancers13143600