Other terms
- Anterior Segment
- Antibody-Drug Conjugates
- Anticoagulation
- Antihistamines
- Apocrine Glands
- Arm
- Arrhythmia
- Arterial Closure
- Astigmatism
- Atherosclerosis
- Atopic Dermatitis
- Atrial Arrhythmia
Angiogenesis
What is Angiogenesis? Angiogenesis is the process of forming new blood vessels regulated by specific proteins synthesized within the body. While angiogenesis facilitates the process of normal tissue growth and wound healing, it can have detrimental effects when this process occurs near cancer cells. The formation of new blood vessels in proximity to cancerous cells provides these cells with essential oxygen and nutrients, promoting their proliferation and potential metastasis.
Angiogenesis and Tumor Growth
Solid tumors proliferate only with a steady supply of oxygen and vital nutrients through blood vessels. Cancerous cells ensure access to a blood supply by upregulating various growth proteins such as Vascular Endothelial Growth Factor (VEGF) and Basic Fibroblast Growth Factor (bFGF) to recruit cells to form new blood vessels around it.
How do Angiogenesis Inhibitors Work?
Angiogenesis inhibitors are unique cancer-fighting compounds developed to block the growth and development of new blood vessels around tumors, thereby cutting off support for new tumor growth. Most angiogenesis inhibitors bind to VEGF, its receptors, or other cells and proteins along the signaling pathways.
