Vial Announces Dosing of First Patient in Phase 1 Healthy Volunteer Trial
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IL‑31 x IL‑4Rα

VIAL‑IL31xIL4Rα is a half‑life–extended bispecific antibody that targets IL‑31 and IL‑4Rα to concurrently block itch neuroinflammation and type‑2 inflammation, aiming for faster onset and more durable control in atopic dermatitis and related Type-2 inflammation conditions.
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  • First-in-class IL‑31 x IL‑4Rα bispecific to raise the efficacy bar in atopic dermatitis by blocking itch neuroinflammation and type‑2 inflammation together.
  • Half‑life extension to enable sustained exposure and less frequent, maintenance‑friendly dosing.

Key Data

Preclinical data indicate a best-in-class dosing interval for patient convenience and efficacy compared to the first and second-generation anti-TL1A candidates.

Graph showing peripheral venous blood-plasma-concentration dosing simulation
Beyond appetite suppression
  • DIO study underway to validate durable response through maintenance of weight loss and preservation of lean muscle mass.
  • Equal-or-better potency in primary human hepatocytes compared to clinical programs.
Low immunogenic risk
  • Low risk of immunogenicity in human PBMCs.

Differentiated Product Profile​

VIAL-TL1A-HLE is potentially a best-in-class anti-TL1A mAb with an extended half-life to support Q9-12M dosing, powered by Vial’s HLE platform. The program is also applicable to MASH, Atopic Dermatitis, SSc-ILD, Rheumatoid Arthritis, Hidradenitis Suppurativa, among others.

Updates

So 1st of all, TL1A Is one of the hot targets at the moment for both Crohn's and Uc. And one of the major challenges that we have in the clinic is to have drugs that need frequent administration and patients like to have drugs that are very effective and that are super safe, and that are easy to administer.

So instead of every 2 weeks, every month, having an injection every 6 months, or once a year, with a very safe mechanism of action. I mean, this is the ideal thing to have for a patient perspective and also for a doctor.

Dr. Silvio Danese
Gastroenterologist, San Raffaele Scientific Institute

A long half-life reduces the burden on the patient hopefully provides a very steady state concentration of drug and binding of the target over the extended half-life, which in theory should be very good at preventing episodic flares.

Dr. Peter Higgins
Gastroenterologist, San Raffaele Scientific Institute

I mean, IBD is a lifelong condition that requires long-term management. Many patients struggle with treatment, fatigue, adherence, challenges, and disruptions in daily life. So an extended half-life TL1A therapeutic, especially one with the potential for once yearly dosing, could significantly improve the quality of life, of reducing injection burden, minimizing clinic visits and maintaining consistent disease control.

Dr. Viral Patel
Gastroenterologist
Press Release
Vial Announces Dosing of First Participants in Phase 1 Healthy Volunteer Trial of a Novel Subcutaneous Half-Life Extended Anti-TL1A Antibody for the Treatment of IBD and Other Inflammatory and Fibrotic Diseases
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