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Subjective Endpoints

What are subjective endpoints? Subjective endpoints are outcomes of a clinical trial that are not based on observable or measurable data but are informed by the symptoms experienced by the subject. Examples of subjective endpoints include pain, depression, and anxiety.

What are the disadvantages of subjective endpoints?

Subjective endpoints are vulnerable to systemic bias as the researcher, the subject, or both may be aware of the subject’s group assignment.

Source: Evans S. R. (2010). Fundamentals of clinical trial design. Journal of experimental stroke & translational medicine, 3(1), 19–27.