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Neuromuscular Transmission

What is Neuromuscular Transmission? Neuromuscular transmission is the process by which nerves transmit electrical impulses to muscles through the neuromuscular junction.

Clinical significance of Neuromuscular Transmission

Interruption of neuromuscular transmission occurs in several disorders through different pathomechanisms affecting specific parts of the signaling process. Muscle response to testing using repeated nerve stimulation can guide further testing for specific diseases.

Impairment of neuromuscular transmission occurs with:

  • Myasthenia Gravis
  • Amyotrophic Lateral Sclerosis
  • Lambert Eaton Syndrome
  • Toxins, including envenomation through snake bites, marine neurotoxins, botulinum, and organophosphates.
  • Medications, such as anesthetic drugs (succinylcholine, rocuronium), bethanechol, carbachol, pilocarpine, and prolonged use of antibiotics and antiarrhythmics.

Source: Jimsheleishvili et al.(2022) Physiology, Neuromuscular Transmission. StatPearls 

[Internet]. Treasure Island (FL): StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK541133/