Other terms
- Enrollment
- Epilepsy
- Epileptologists
- ePRO (Electronic Patient-Reported Outcome)
- Erythema
- eTMF
- Fibrosis
- Fingernail Psoriasis
- Food and Drug Administration (FDA)
- Gastroenterology
- Irritable Bowel Syndrome (IBS)
- Gene therapy
Endpoint
An endpoint is a measure of a primary or secondary outcome of a clinical trial. Endpoints of a clinical trial can be classified as direct/clinical endpoints or surrogate endpoints. A clinically meaningful endpoint that directly measures how a patient, feels, or functions is a clinical endpoint and represents a direct clinical benefit.
Measures of clinical endpoints can include:
- Disease-Free Survival.
- Progression-Free Survival.
- Response Rate.
- Overall Survival.
- Quality of Life.
If the clinical endpoint cannot be feasibly measured, a surrogate endpoint may be used, but will not represent a direct clinical benefit, but acts as a predictive measure for the clinical benefit. For example, blood pressure or cholesterol control may be used as surrogate endpoints for survival.
Surrogate endpoints also offer other advantages:
- Faster and easier to study.
- Faster drug development.
- Cheaper to measure and track.
Source: Clinical Trial Endpoints | Friends of Cancer Research. (n.d.). Friends of Cancer Research. Retrieved January 26, 2022, from https://friendsofcancerresearch.org/clinical-trial-endpoints.
