What is Cirrhosis? Cirrhosis, also known as Liver or Hepatic Cirrhosis, is a condition caused by inflammatory damage to the liver tissue, leading to fibrotic scar tissue formation.

Liver cirrhosis is characterized by several stages, including asymptomatic, compensated, and decompensated cirrhosis. In some diseases, cirrhosis may be reversible to an extent. However, cirrhosis may be irreversible with severe, untreated liver disease and lead to end-organ failure. 


What Causes Cirrhosis?

Causes of cirrhosis include:

  • Chronic viral hepatitis, including Hepatitis B and C
  • Alcoholic liver disease
  • Non-alcoholic fatty liver disease
  • Hemochromatosis
  • Autoimmune hepatitis
  • Alpha-1 antitrypsin deficiency
  • Wilson disease


Signs and Symptoms of Cirrhosis

  • Nonspecific symptoms such as fatigue, anorexia, weight loss, and weakness
  • Jaundice
  • Pruritis
  • Abdominal pain
  • Swelling in legs or abdomen
  • Spider angiomas
  • Asterixis
  • Palmar erythema
  • Coagulation abnormalities
  • Confusion

Source: Liu, Y., & Chen, M. (2022). Epidemiology of liver cirrhosis and associated complications: Current knowledge and future directions. World Journal of Gastroenterology, 28(41), 5910–5930.