Advanced Lung Squamous Cell Carcinoma (LUSC)

What is Advanced Lung Squamous Cell Carcinoma (LUSC)? Lung Squamous Cell Carcinoma is a type of non-small cell lung cancer (NSCLC), accounting for 30% of the cases. It often occurs in the central part of the lung, such as the trachea or the left or right bronchus, but has also been found in the peripheral portions of the lung.

During the early stages of lung cancer, curative treatment includes surgical excision. However, most lung cancers are diagnosed late. Once the lung squamous cell carcinoma can no longer be completely treated with surgery, it is considered to be in advanced stages.


What causes Lung Squamous Cell Carcinoma?

Although the exact pathomechanism of the development of LUSC has not been elucidated, alteration in the regulation of several hundred genes has been identified. LUSC is characterized by metaplasia of the epithelial lining of the respiratory tract, including changes in the histology of the cells that may or may not include keratinization, and a high degree of mutations.


Risk factors of lung squamous cell carcinoma include:

  • Smoking
  • Age- more common in middle-aged and elderly men
  • Positive family history
  • Exposure to secondhand smoke or other carcinogens, such as asbestos, and mineral and metal particulate matter

Source: Gao, M., Kong, W., Huang, Z., & Xie, Z. (2020). Identification of Key Genes Related to Lung Squamous Cell Carcinoma Using Bioinformatics Analysis. International Journal of Molecular Sciences, 21(8), 2994.