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Scientific Name: Zidovudine
Brand Name: Combivir, Retrovir, Trizivir
Company Owner: Viiv healthcare co, Aurobindo pharma ltd inc, Cipla ltd, Pharmaforce inc, Aurobindo pharma ltd, Hetero drugs ltd unit iii, Matrix laboratories ltd, Ranbaxy laboratories ltd, Roxane laboratories inc
Mechanism Of Action Zidovudine, a structural analog of thymidine, is a prodrug that must be phosphorylated to its active 5′-triphosphate metabolite, zidovudine triphosphate (ZDV-TP) . It inhibits the activity of HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleotide analogue. It competes with the natural substrate dGTP and incorporates itself into viral DNA. It is also a weak inhibitor of cellular DNA polymerase α and γ.
Description of the Drug: Zidovudine is a dideoxynucleoside used in the treatment of HIV infection.
Protein Data Bank:
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB00495