Zidovudine
Back to search| Scientific Name: | Zidovudine |
| Brand Name: | Combivir, Retrovir, Trizivir |
| Company Owner: | Viiv healthcare co, Aurobindo pharma ltd inc, Cipla ltd, Pharmaforce inc, Aurobindo pharma ltd, Hetero drugs ltd unit iii, Matrix laboratories ltd, Ranbaxy laboratories ltd, Roxane laboratories inc |
| Mechanism Of Action | Zidovudine, a structural analog of thymidine, is a prodrug that must be phosphorylated to its active 5′-triphosphate metabolite, zidovudine triphosphate (ZDV-TP) . It inhibits the activity of HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleotide analogue. It competes with the natural substrate dGTP and incorporates itself into viral DNA. It is also a weak inhibitor of cellular DNA polymerase α and γ. |
| Description of the Drug: | Zidovudine is a dideoxynucleoside used in the treatment of HIV infection. |
| Protein Data Bank: |
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB00495
