Varenicline
Back to search| Scientific Name: | Varenicline |
| Brand Name: | Champix, Chantix, Tyrvaya |
| Company Owner: | Not Available |
| Mechanism Of Action | Varenicline is an alpha-4 beta-2 neuronal nicotinic acetylcholine receptor partial agonist. The drug shows high selectivity for this receptor subclass, relative to other nicotinic receptors (>500-fold alpha-3 beta-4, >3500-fold alpha-7, >20, 000-fold alpha-1 beta gamma delta) or non-nicotinic receptors and transporters (>2000-fold) . The drug competitively inhibits the ability of nicotine to bind to and activate the alpha-4 beta-2 receptor. The drug exerts mild agonistic activity at this site, though at a level much lower than nicotine; it is presumed that this activation eases withdrawal symptoms. |
| Description of the Drug: | Varenicline is a partial agonist at nicotinic acetylcholine receptors used as an aid in smoking cessation. |
| Protein Data Bank: |
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB01273
