Valrubicin

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Scientific Name: Valrubicin
Brand Name: Valstar
Company Owner: Endo pharmaceutical solutions inc
Mechanism Of Action Valrubicin is an anthracycline that affects a variety of inter-related biological functions, most of which involve nucleic acid metabolism. It readily penetrates into cells, where after DNA intercalation, it inhibits the incorporation of nucleosides into nucleic acids, causes extensive chromosomal damage, and arrests cell cycle in G2. Although valrubicin does not bind strongly to DNA, a principal mechanism of its action, mediated by valrubicin metabolites, is interference with the normal DNA breaking-resealing action of DNA topoisomerase II.
Description of the Drug: Valrubicin is an anthracycline used intravesically in the treatment of BCG-resistant bladder carcinoma.
Protein Data Bank: Not Available
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB00385