Trimethadione
Back to search| Scientific Name: | Trimethadione |
| Brand Name: | Not Available |
| Company Owner: | Abbott laboratories pharmaceutical products div |
| Mechanism Of Action | Dione anticonvulsants reduce T-type calcium currents in thalamic neurons, including thalamic relay neurons. It does so via the inhibition of voltage dependent T-type calcium channels. This raises the threshold for repetitive activity in the thalamus, and inhibits corticothalamic transmission. Thus, the abnormal thalamocortical rhythmicity, which is thought to underlie the 3-Hz spike-and-wave discharge seen on electroencephalogram(EEG) with absence seizures, is dampened. |
| Description of the Drug: | Trimethadione is an anticonvulsant agent indicated for the control of treatment-refractory petit mal seizures. |
| Protein Data Bank: | Not Available |
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB00347
