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Scientific Name: Trimethadione
Brand Name: Not Available
Company Owner: Abbott laboratories pharmaceutical products div
Mechanism Of Action Dione anticonvulsants reduce T-type calcium currents in thalamic neurons, including thalamic relay neurons. It does so via the inhibition of voltage dependent T-type calcium channels. This raises the threshold for repetitive activity in the thalamus, and inhibits corticothalamic transmission. Thus, the abnormal thalamocortical rhythmicity, which is thought to underlie the 3-Hz spike-and-wave discharge seen on electroencephalogram(EEG) with absence seizures, is dampened.
Description of the Drug: Trimethadione is an anticonvulsant agent indicated for the control of treatment-refractory petit mal seizures.
Protein Data Bank: Not Available
Source: DrugBank Online – Retrieved 2023-01-23 from