Topotecan
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Scientific Name
Topotecan
Description of the Drug
Topotecan is an antineoplastic agent used to treat ovarian cancer, small cell lung cancer, or cervical cancer.
Source: DrugBank Online – DrugBank.com. Retrieved 2023-03-10 from
http://www.drugbank.ca/drugs/DB01030
http://www.drugbank.ca/drugs/DB01030
Brand Name(s)
Hycamtin, Potactasol
Company Owner(s)
Fresenius Kabi Usa Llc, Mylan Laboratories Ltd, Sandoz Inc, Sagent Pharmaceuticals Inc, Hospira Inc, Sun Pharmaceutical Industries Ltd, Actavis Totowa Llc, Novartis Pharmaceuticals Corp, Novast Laboratories Ltd, Teyro Labs Private Ltd
Mechanism(s) Of Action
| Target Name | Target Type | Action Type | Target ChEMBL ID |
|---|---|---|---|
| DNA topoisomerase I, mitochondrial | SINGLE PROTEIN | INHIBITOR | CHEMBL2362989 |
Clinical Trial(s)
Unichem Links
| SureChEMBL | SCHEMBL3836 | ||||
| PharmGKB | PA451729 | ||||
| Human Metabolome Database | HMDB0015164 | ||||
| DrugBank | DB01030 | ||||
| PubChem: Thomson Pharma | 14904851 | 14807035 | |||
| PubChem | 60700 | ||||
| LINCS | LSM-5662 | ||||
| Nikkaji | J2.256.755A | J362.027A | J2.256.757H | ||
| PDBe | TTC | ||||
| BindingDB | 50034026 | 50008935 | |||
| EPA CompTox Dashboard | DTXSID3042685 | ||||
| DrugCentral | 2707 | ||||
| Brenda | 153416 | 230151 | 154401 | 4873 | 230152 |
| ChemicalBook | CB1339804 | ||||
| Guide to Pharmacology | 7101 | ||||
| rxnorm | TOPOTECAN | HYCAMTIN | TOPOTECAN HYDROCHLORIDE | ||
| KEGG Ligand | C11158 | ||||
| ChEBI | 63632 | ||||
| ZINC | ZINC000001611274 |
