Topiramate
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Scientific Name
Topiramate
Description of the Drug
Topiramate is an anticonvulsant drug used in the control of epilepsy and in the prophylaxis and treatment of migraines.
Source: DrugBank Online – DrugBank.com. Retrieved 2023-03-10 from
http://www.drugbank.ca/drugs/DB00273
http://www.drugbank.ca/drugs/DB00273
Brand Name(s)
Epitomax, Eprontia, Qudexy xr, Topamax, Topamax sprinkle, Topiramate, Trokendi xr
Company Owner(s)
Cipla Ltd, Invagen Pharmaceuticals Inc, Watson Laboratories Inc, Mylan Pharmaceuticals Inc, Chartwell Life Molecules Llc, Atlantide Pharmaceuticals Ag, Zydus Pharmaceuticals Usa Inc, Torrent Pharmaceuticals Ltd, Supernus Pharmaceuticals Inc, Teva Pharmaceuticals Usa Inc
Mechanism(s) Of Action
| Target Name | Target Type | Action Type | Target ChEMBL ID |
|---|---|---|---|
| Carbonic anhydrase IV | SINGLE PROTEIN | INHIBITOR | CHEMBL3729 |
| Sodium channel alpha subunit | PROTEIN FAMILY | BLOCKER | CHEMBL2331043 |
| GABA-A receptor; anion channel | PROTEIN COMPLEX GROUP | POSITIVE MODULATOR | CHEMBL2093872 |
| Glutamate receptor ionotropic kainate | PROTEIN COMPLEX GROUP | ANTAGONIST | CHEMBL2109241 |
| Glutamate receptor ionotropic AMPA | PROTEIN COMPLEX GROUP | ANTAGONIST | CHEMBL2096670 |
| Carbonic anhydrase II | SINGLE PROTEIN | INHIBITOR | CHEMBL205 |
Clinical Trial(s)
Unichem Links
| Atlas | topiramate | ||
| SureChEMBL | SCHEMBL34631 | ||
| PharmGKB | PA451728 | ||
| Human Metabolome Database | HMDB0005034 | ||
| DrugBank | DB00273 | ||
| PubChem: Thomson Pharma | 14777895 | 14924784 | |
| PubChem | 5284627 | ||
| Mcule | MCULE-9403222429 | ||
| LINCS | LSM-5435 | ||
| Nikkaji | J345.989F | ||
| PDBe | TOR | ||
| BindingDB | 10887 | ||
| EPA CompTox Dashboard | DTXSID8023688 | ||
| DrugCentral | 2706 | ||
| Brenda | 166019 | 191445 | 227498 |
| ChemicalBook | CB7402630 | ||
| Guide to Pharmacology | 6849 | ||
| rxnorm | QUDEXY | TOPAMAX | TOPIRAMATE |
| PubChem: Drugs of the Future | 12013555 | ||
| KEGG Ligand | C07502 | ||
| ChEBI | 63631 | ||
| ZINC | ZINC000095616603 |
