Tirbanibulin

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Scientific Name: Tirbanibulin
Brand Name: Klisyri
Company Owner: Not Available
Mechanism Of Action Src tyrosine kinases regulate normal cell growth: the expression of Src kinase is upregulated during the normal hair cycle during the proliferative anagen phase. Additionally, Src tyrosine kinases act as key modulators of cancer cell proliferation, survival, angiogenesis, migration, invasion and metastasis. Src is frequently upregulated in various epithelial tumours including colon, breast and pancreas compared with the adjacent normal tissues. The expression and activity of Src are also enhanced in human actinic keratosis, which is characterized by hyperproliferative premalignant skin lesions.
Description of the Drug: Tirbanibulin is a tyrosine kinase and tubulin inhibitor used to treat actinic keratosis on the face or scalp.
Protein Data Bank:
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB06137