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Scientific Name: Tioconazole
Brand Name: Monistat Simple Therapy, Vagistat
Company Owner: Pfizer laboratories div pfizer inc, L perrigo co, Novartis consumer health inc
Mechanism Of Action Tioconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. In this way, tioconazole inhibits ergosterol synthesis, resulting in increased cellular permeability. Tioconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms and the uptake of purine, impair triglyceride and/or phospholipid biosynthesis, and inhibit the movement of calcium and potassium ions across the cell membrane by blocking the ion transport pathway known as the Gardos channel.
Description of the Drug: Tioconazole is an imidazole antifungal used to treat vulvovaginal candidiasis.
Protein Data Bank: Not Available
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB01007