Spironolactone
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Scientific Name
Spironolactone
Description of the Drug
Spironolactone is an aldosterone receptor antagonist used for the treatment of hypertension, hyperaldosteronism, edema due to various conditions, hirsutism (off-label) and hypokalemia.
http://www.drugbank.ca/drugs/DB00421
Brand Name(s)
Abbolactone, Aldactone, Carospir, Diatensec, Gx spironol, Laractone, Spiretic, Spiroctan 100, Spiroctan 25, Spiroctan 50, Spironolactone, Spirospare 100, Spirospare 25
Company Owner(s)
Cmp Development Llc, Jubilant Generics Ltd, Sun Pharmaceutical Industries Inc, Ascot Hosp Pharmaceuticals Inc Div Travenol Laboratories Inc, Watson Laboratories Inc, Mylan Pharmaceuticals Inc, Purepac Pharmaceutical Co, Amneal Pharmaceuticals Of New York Llc, Zydus Pharmaceuticals Usa Inc, Lederle Laboratories Div American Cyanamid Co
Mechanism(s) Of Action
Target Name | Target Type | Action Type | Target ChEMBL ID |
---|---|---|---|
Mineralocorticoid receptor | SINGLE PROTEIN | ANTAGONIST | CHEMBL1994 |
Clinical Trial(s)
Unichem Links
SureChEMBL | SCHEMBL20939 | ||
PharmGKB | PA451483 | ||
Human Metabolome Database | HMDB0014565 | ||
DrugBank | DB00421 | ||
PubChem: Thomson Pharma | 14782265 | 14855731 | |
PubChem | 5833 | ||
Mcule | MCULE-4394091100 | ||
LINCS | LSM-4018 | ||
Nikkaji | J4.474A | ||
PDBe | SNL | ||
BindingDB | 50228080 | ||
EPA CompTox Dashboard | DTXSID6034186 | ||
DrugCentral | 2475 | ||
ChemicalBook | CB9743463 | ||
Guide to Pharmacology | 2875 | ||
rxnorm | SPIRONOLACTONE | CAROSPIR | ALDACTONE |
PubChem: Drugs of the Future | 22395181 | ||
KEGG Ligand | C07310 | ||
ChEBI | 9241 | ||
ZINC | ZINC000003861599 |