Samidorphan
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Scientific Name
Samidorphan
Description of the Drug
Samidorphan is a novel opioid-system modulator, similar to naltrexone, that functions primarily as a μ-opioid receptor antagonist in vivo and is used primarily in combination with antipsychotics to reduce their metabolic dysfunction-associated adverse effects.
Source: DrugBank Online – DrugBank.com. Retrieved 2023-03-10 from
http://www.drugbank.ca/drugs/DB12543
http://www.drugbank.ca/drugs/DB12543
Brand Name(s)
Not Available
Company Owner(s)
Alkermes Inc
Mechanism(s) Of Action
| Target Name | Target Type | Action Type | Target ChEMBL ID |
|---|---|---|---|
| Mu opioid receptor | SINGLE PROTEIN | ANTAGONIST | CHEMBL233 |
| Kappa opioid receptor | SINGLE PROTEIN | PARTIAL AGONIST | CHEMBL237 |
| Delta opioid receptor | SINGLE PROTEIN | PARTIAL AGONIST | CHEMBL236 |
Clinical Trial(s)
Unichem Links
| SureChEMBL | SCHEMBL2786239 | |
| DrugBank | DB12543 | |
| PubChem: Thomson Pharma | 16771664 | |
| PubChem | 11667832 | |
| BindingDB | 50165049 | 50278265 |
| Guide to Pharmacology | 10651 | |
| ChEBI | 177605 | |
| ZINC | ZINC000028478244 |
