Nitisinone
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Scientific Name
Nitisinone
Description of the Drug
Nitisinone is a hydroxyphenylpyruvate dioxygenase inhibitor used as an adjunct to dietary restrictions for the treatment of hereditary tyrosinemia type 1 (HT-1), which causes intolerance to tyrosine containing foods.
Source: DrugBank Online – DrugBank.com. Retrieved 2023-03-10 from
http://www.drugbank.ca/drugs/DB00348
http://www.drugbank.ca/drugs/DB00348
Brand Name(s)
Nityr, Orfadin
Company Owner(s)
Novitium Pharma Llc, Medunik Canada Inc, Cycle Pharmaceuticals Ltd, Swedish Orphan Biovitrum Ab Publ
Mechanism(s) Of Action
| Target Name | Target Type | Action Type | Target ChEMBL ID |
|---|---|---|---|
| 4-hydroxyphenylpyruvate dioxygenase | SINGLE PROTEIN | INHIBITOR | CHEMBL1861 |
Clinical Trial(s)
Unichem Links
| SureChEMBL | SCHEMBL338795 | |||||
| PharmGKB | PA164777037 | |||||
| Human Metabolome Database | HMDB0014492 | |||||
| DrugBank | DB00348 | |||||
| PubChem: Thomson Pharma | 14753104 | |||||
| PubChem | 115355 | |||||
| Mcule | MCULE-6109734568 | |||||
| BindingDB | 50088804 | |||||
| EPA CompTox Dashboard | DTXSID9042673 | |||||
| DrugCentral | 1944 | |||||
| Brenda | 219880 | 219930 | 219883 | 135218 | 151008 | 23285 |
| ChemicalBook | CB61386686 | |||||
| Guide to Pharmacology | 6834 | |||||
| rxnorm | NITISINONE | ORFADIN | NITYR | |||
| ChEBI | 50378 | |||||
| ZINC | ZINC000100014475 |
