Methotrexate
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Scientific Name
Methotrexate
Description of the Drug
Methotrexate is an antineoplastic agent used the treatment of a wide variety of cancers as well as severe psoriasis, severe rheumatoid arthritis, and juvenile rheumatoid arthritis.
Source: DrugBank Online – DrugBank.com. Retrieved 2023-03-10 from
http://www.drugbank.ca/drugs/DB00563
http://www.drugbank.ca/drugs/DB00563
Brand Name(s)
Amethopterin, Ebetrex, Emtexate high-pot, Emtexate pf, Folex, Maxtrex, Methotrexate, Metoject, Mexate, Otrexup, Otrexup pfs, Rasuvo, Reditrex, Rheumatrex, Trexall, Zlatal
Company Owner(s)
Lotus Pharmaceutical Co Ltd Nantou Plant, Bristol Myers Squibb, Otter Pharmaceuticals Llc, Duramed Pharmaceuticals Inc Sub Barr Laboratories Inc, Mylan Pharmaceuticals Inc, Amneal Pharmaceuticals Of New York Llc, Zydus Pharmaceuticals Usa Inc, Fresenius Kabi Usa Llc, Hospira Inc, Bristol Myers Co
Mechanism(s) Of Action
| Target Name | Target Type | Action Type | Target ChEMBL ID |
|---|---|---|---|
| Dihydrofolate reductase | SINGLE PROTEIN | INHIBITOR | CHEMBL202 |
Clinical Trial(s)
Unichem Links
| SureChEMBL | SCHEMBL3711 | ||||||||||
| PharmGKB | PA450428 | ||||||||||
| Human Metabolome Database | HMDB0014703 | ||||||||||
| DrugBank | DB00563 | ||||||||||
| PubChem: Thomson Pharma | 14760074 | 14808762 | |||||||||
| PubChem | 126941 | ||||||||||
| Mcule | MCULE-6523054194 | ||||||||||
| NMRShiftDB | 80020728 | ||||||||||
| LINCS | LSM-5690 | ||||||||||
| Nikkaji | J2.334E | ||||||||||
| PDBe | MTX | ||||||||||
| BindingDB | 66082 | 18050 | |||||||||
| EPA CompTox Dashboard | DTXSID4020822 | ||||||||||
| DrugCentral | 1751 | ||||||||||
| Brenda | 39751 | 91627 | 132028 | 49198 | 3613 | 229641 | 138514 | 241 | 220748 | 229642 | 9550 |
| ChemicalBook | CB2704227 | CB2739302 | |||||||||
| Guide to Pharmacology | 4674 | 4815 | |||||||||
| rxnorm | REDITREX | XATMEP | METHOTREXATE SODIUM | RASUVO | METHOTREXATE | OTREXUP | TREXALL | ||||
| PubChem: Drugs of the Future | 22395177 | ||||||||||
| KEGG Ligand | C01937 | ||||||||||
| ChEBI | 44185 | ||||||||||
| ZINC | ZINC000001529323 |
