Molecule Structure

Scientific Name

Metformin

Description of the Drug

Metformin is a biguanide antihyperglycemic used in conjunction with diet and exercise for glycemic control in type 2 diabetes mellitus. It is also used off-label for insulin resistance in polycystic ovary syndrome (PCOS).

Source: DrugBank Online – DrugBank.com. Retrieved 2023-03-10 from
http://www.drugbank.ca/drugs/DB00331

Brand Name(s)

Not Available

Company Owner(s)

Sunshine Lake Pharma Co Ltd, Alkem Laboratories Ltd, Bristol Myers Squibb, Takeda Pharmaceuticals Usa Inc, Sun Pharmaceutical Industries Inc, Macleods Pharmaceuticals Ltd, Watson Laboratories Inc, Laurus Labs Ltd, Yichang Humanwell Pharmaceutical Co Ltd, Mylan Pharmaceuticals Inc

Mechanism(s) Of Action

Target Name Target Type Action Type Target ChEMBL ID
Mitochondrial glycerol-3-phosphate dehydrogenase SINGLE PROTEIN INHIBITOR CHEMBL3391681
Mitochondrial complex I (NADH dehydrogenase) PROTEIN COMPLEX INHIBITOR CHEMBL2363065

Unichem Links

Atlas metformin
SureChEMBL SCHEMBL8944
PharmGKB PA450395
Human Metabolome Database HMDB0001921
DrugBank DB00331
PubChem: Thomson Pharma 15297229
PubChem 4091 155906370
Mcule MCULE-7393156510
LINCS LSM-4730
Nikkaji J9.463C
PDBe MF8
BindingDB 57047 50229665
EPA CompTox Dashboard DTXSID2023270
DrugCentral 1725
ChemicalBook CB0506294 CB22706988
Guide to Pharmacology 4779 4503
rxnorm GLUMETZA METFORMIN RIOMET JANUMET GLUCOPHAGE METFORMIN HYDROCHLORIDE FORTAMET
KEGG Ligand C07151
ChEBI 6801
ZINC ZINC000012859773