Mebendazole

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Scientific Name: Mebendazole
Brand Name: Emverm, Vermox
Company Owner: Teva pharmaceuticals usa, Mcneil pediatrics
Mechanism Of Action Mebendazole causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP) , which is the energy required for the survival of the helminth. Due to diminished energy production, the parasite is immobilized and eventually dies.
Description of the Drug: Mebendazole is a benzimidazole anthelmintic used to treat helminth infections.
Protein Data Bank:
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB00643