Scientific Name: Malathion
Brand Name: Ovide
Company Owner: Synerx pharma llc, Taro pharmaceuticals north america inc
Mechanism Of Action Malathion is a nonsystemic, wide-spectrum organophosphate insecticide. It inhibits acetylcholinesterase activity of most eukaryotes. Malathion is toxic to aquatic organisms, but has a relatively low toxicity for birds and mammals. The major metabolites of malathion are mono- and di-carboxylic acid derivatives, and malaoxon is a minor metabolite. However, it is malaoxon that is the strongest cholinesterase inhibitor. Cholinesterases catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. Because of its essential function, chemicals that interfere with the action of cholinesterase are potent neurotoxins, causing muscle spasms and ultimately death.
Description of the Drug: Malathion is a parasympathomimetic organophosphate used to treat head lice.
Protein Data Bank: Not Available
Source: DrugBank Online – Retrieved 2023-01-23 from