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Scientific Name: Lumacaftor
Brand Name: Orkambi
Company Owner: Not Available
Mechanism Of Action Lumacaftor improves CF symptoms and underlying disease pathology by aiding the conformational stability of F508del-mutated CFTR, resulting in increased processing and trafficking of mature protein to the cell surface.
Description of the Drug: Lumacaftor is a protein chaperone used in combination with ivacaftor for the treatment of cystic fibrosis in patients who are homozygous for the F508del mutation in the CFTR gene.
Protein Data Bank:
Source: DrugBank Online – Retrieved 2023-01-23 from