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Scientific Name: Leucovorin
Brand Name: EnBrace HR, EnLyte, Lederle Leucovorin
Company Owner: Hospira inc, Abic ltd, Abraxis pharmaceutical products, Bedford laboratories div ben venue laboratories inc, Elkins sinn div ah robins co inc, Pharmachemie bv, Pharmachemie usa inc, Teva parenteral medicines inc, App pharmaceuticals llc, Luitpold pharmaceuticals inc, Glaxosmithkline, Barr pharmaceuticals, Corepharma llc, Par pharmaceutical inc, Roxane laboratories inc, Sandoz inc, Xanodyne pharmaceutics inc, Spectrum pharmaceuticals inc
Mechanism Of Action As leucovorin is a derivative of folic acid, it can be used to increase levels of folic acid under conditions favoring folic acid inhibition (following treatment of folic acid antagonists such as methotrexate) . Leucovorin enhances the activity of fluorouracil by stabilizing the bond of the active metabolite (5-FdUMP) to the enzyme thymidylate synthetase.
Description of the Drug: Leucovorin is a folate analog used to treat the toxic effects of methotrexate and other folate antagonists, to treat megaloblastic anemia, and to provide palliative treatment of colorectal cancer.
Protein Data Bank: Not Available
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB00650