Lacosamide

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Scientific Name: Lacosamide
Brand Name: Vimpat
Company Owner: Not Available
Mechanism Of Action It is proposed that lacosamide’s inhibition of sodium channels is responsible for analgesia. Lacosamide may be selective for inhibiting depolarized neurons rather than neurons with normal resting potentials. Pain and nociceptor hyperexcitability are associated with neural membrane depolarization. Lacosamide binds to collapsin response mediator protein-2 (CRMP-2) , a phosphoprotein which is expressed primarily in the nervous system and is involved in neuronal differentiation and control of axonal outgrowth. The role CRMP-2 of binding in seizure control is hasn’t been elucidated.
Description of the Drug: Lacosamide is an antiepileptic drug used to treat partial onset seizures in adults.
Protein Data Bank: Not Available
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB06218