Ketoprofen

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Scientific Name: Ketoprofen
Brand Name: Not Available
Company Owner: Elan pharmaceutical research corp, Mylan pharmaceuticals inc, Watson laboratories inc florida, Wyeth pharmaceuticals inc, Heritage pharmaceuticals inc, Sandoz inc, Teva pharmaceuticals usa inc, Wyeth ayerst laboratories, Novartis consumer health inc, Bayer healthcare llc, L perrigo co, Wyeth consumer healthcare
Mechanism Of Action The anti-inflammatory effects of ketoprofen are believed to be due to inhibition cylooxygenase-2 (COX-2) , an enzyme involved in prostaglandin synthesis via the arachidonic acid pathway. This results in decreased levels of prostaglandins that mediate pain, fever and inflammation. Ketoprofen is a non-specific cyclooxygenase inhibitor and inhibition of COX-1 is thought to confer some of its side effects, such as GI upset and ulceration. Ketoprofen is thought to have anti-bradykinin activity, as well as lysosomal membrane-stabilizing action. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.
Description of the Drug: Ketoprofen is an NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, dysmenorrhea, mild to moderate muscle pain, postoperative pain, and postpartum pain.
Protein Data Bank: Not Available
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB01009