Molecule Structure

Scientific Name

Ivacaftor

Description of the Drug

Ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator used alone or in combination products to treat cystic fibrosis in patients who have specific genetic mutations that are responsive to the medication.

Source: DrugBank Online – DrugBank.com. Retrieved 2023-03-10 from
http://www.drugbank.ca/drugs/DB08820

Brand Name(s)

Kalydeco

Company Owner(s)

Vertex Pharmaceuticals Inc

Mechanism(s) Of Action

Target Name Target Type Action Type Target ChEMBL ID
Cystic fibrosis transmembrane conductance regulator SINGLE PROTEIN POSITIVE MODULATOR CHEMBL4051

Unichem Links

SureChEMBL SCHEMBL351373
PharmGKB PA165950341
Human Metabolome Database HMDB0015705
DrugBank DB08820
PubChem: Thomson Pharma 24902571
PubChem 16220172
LINCS LSM-45975
Nikkaji J3.163.539J
PDBe VX7
BindingDB 50032693
EPA CompTox Dashboard DTXSID00236281
DrugCentral 4228
ChemicalBook CB32506174
Guide to Pharmacology 4342
rxnorm IVACAFTOR KALYDECO
PubChem: Drugs of the Future 125299328
ChEBI 66901
ZINC ZINC000052509463