Isavuconazonium
Back to search| Scientific Name: | Isavuconazonium |
| Brand Name: | Cresemba |
| Company Owner: | Not Available |
| Mechanism Of Action | Antifungals in the triazole class, such as isavuconazonium, target and inhibit the sterol 14-α-demethylase (Erg11p) which is a key player in the demethylation step of the ergosterol biosynthetic pathway. This inhibition results in a halt in production of ergosterol, a molecule typically found in the membranes of fungi such as Aspergillus, Candida, and Mucorales that plays a role in regulation of membrane integrity, fluidity and permeability. The inhibition of Erg11p also causes the buildup of ergosterol precursors, which are toxic and cause cell death. |
| Description of the Drug: | Isavuconazonium is a triazole antifungal used for the treatment of invasive aspergillosis and mucormycosis. |
| Protein Data Bank: | Not Available |
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB06636
