Hydroxocobalamin

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Scientific Name: Hydroxocobalamin
Brand Name: Cyanokit, Hydro-Cobex
Company Owner: Merck and co inc, Merck sante sas, Abraxis pharmaceutical products, Watson laboratories inc, Bel mar laboratories inc
Mechanism Of Action Vitamin B12 exists in four major forms referred to collectively as cobalamins; deoxyadenosylcobalamin, methylcobalamin, hydroxocobalamin, and cyanocobalamin. Two of these, methylcobalamin and 5-deoxyadenosyl cobalamin, are primarily used by the body. Methionine synthase needs methylcobalamin as a cofactor. This enzyme is involved in the conversion of the amino acid homocysteine into methionine. Methionine in turn is required for DNA methylation. 5-Deoxyadenosyl cobalamin is a cofactor needed by the enzyme that converts L-methylmalonyl-CoA to succinyl-CoA. This conversion is an important step in the extraction of energy from proteins and fats. Furthermore, succinyl CoA is necessary for the production of hemoglobin, the substances that carries oxygen in red blood cells.
Description of the Drug: Hydroxocobalamin is a synthetic form of vitamin B12 used to treat vitamin B12 associated disorders and cyanide poisoning.
Protein Data Bank: Not Available
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB00200