Gramicidin D

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Scientific Name: Gramicidin D
Brand Name: Sofracort, Soframycin, Triple Antibiotic, Viaderm Kc
Company Owner: Not Available
Mechanism Of Action Gramicidin D binds to and inserts itself into bacterial membranes (with a strong preference to gram-positive cell membranes) . This results in membrane disruption and permeabilization (it acts as a channel) . This leads to (i) loss of intracellular solutes (e. g. , K+ and amino acids) ; (ii) dissipation of the transmembrane potential; (iii) inhibition of respiration; (iv) a reduction in ATP pools; and (v) inhibition of DNA, RNA, and protein synthesis, which leads to cell death.
Description of the Drug: Gramicidin D is a bactericidal antibiotic used in the treatment of dermatological and ophthalmic infections.
Protein Data Bank: Not Available
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB00027