Gramicidin D
Back to search| Scientific Name: | Gramicidin D |
| Brand Name: | Sofracort, Soframycin, Triple Antibiotic, Viaderm Kc |
| Company Owner: | Not Available |
| Mechanism Of Action | Gramicidin D binds to and inserts itself into bacterial membranes (with a strong preference to gram-positive cell membranes) . This results in membrane disruption and permeabilization (it acts as a channel) . This leads to (i) loss of intracellular solutes (e. g. , K+ and amino acids) ; (ii) dissipation of the transmembrane potential; (iii) inhibition of respiration; (iv) a reduction in ATP pools; and (v) inhibition of DNA, RNA, and protein synthesis, which leads to cell death. |
| Description of the Drug: | Gramicidin D is a bactericidal antibiotic used in the treatment of dermatological and ophthalmic infections. |
| Protein Data Bank: | Not Available |
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB00027
