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Scientific Name: Gonadorelin
Brand Name: Lutrepulse
Company Owner: Ferring pharmaceuticals inc, Baxter healthcare corp anesthesia critical care
Mechanism Of Action Systemic – Like naturally occurring gonadotropin-releasing hormone (GnRH) , gonadorelin primarily stimulates the synthesis and release of luteinizing hormone (LH) from the anterior pituitary gland. Follicle-stimulating hormone (FSH) production and release is also increased by gonadorelin, but to a lesser degree. In prepubertal females and some gonadal function disorders, the FSH response may be greater than the LH response. For the treatment of amenorrhea, delayed puberty, and infertility the administration of gonadorelin is used to simulate the physiologic release of GnRH from the hypothalamus in treatment of delayed puberty, treatment of infertility caused by hypogonadotropic hypogonadism, and induction of ovulation in those women with hypothalamic amenorrhea. This results in increased levels of pituitary gonadotropins LH and FSH, which subsequently stimulate the gonads to produce reproductive steroids.
Description of the Drug: Gonadorelin is a synthetic GnRH used to test the function of gonadotropes and the pituitary.
Protein Data Bank: Not Available
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB00644