Gliclazide
Back to search| Scientific Name: | Gliclazide |
| Brand Name: | Diamicron |
| Company Owner: | Not Available |
| Mechanism Of Action | Gliclazide binds to the β cell sulfonyl urea receptor (SUR1) . This binding subsequently blocks the ATP sensitive potassium channels. The binding results in closure of the channels and leads to a resulting decrease in potassium efflux leads to depolarization of the β cells. This opens voltage-dependent calcium channels in the β cell resulting in calmodulin activation, which in turn leads to exocytosis of insulin containing secretorty granules. |
| Description of the Drug: | Gliclazide is a sulfonylurea used to treat hyperglycemia in patients with type 2 diabetes mellitus. |
| Protein Data Bank: |
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB01120
