Gliclazide

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Scientific Name: Gliclazide
Brand Name: Diamicron
Company Owner: Not Available
Mechanism Of Action Gliclazide binds to the β cell sulfonyl urea receptor (SUR1) . This binding subsequently blocks the ATP sensitive potassium channels. The binding results in closure of the channels and leads to a resulting decrease in potassium efflux leads to depolarization of the β cells. This opens voltage-dependent calcium channels in the β cell resulting in calmodulin activation, which in turn leads to exocytosis of insulin containing secretorty granules.
Description of the Drug: Gliclazide is a sulfonylurea used to treat hyperglycemia in patients with type 2 diabetes mellitus.
Protein Data Bank:
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB01120