Ganciclovir

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Scientific Name: Ganciclovir
Brand Name: Cytovene, Zirgan
Company Owner: Roche palo alto llc, Ranbaxy laboratories ltd, Bausch and lomb inc, App pharmaceuticals llc, Bedford laboratories div ben venue laboratories inc
Mechanism Of Action Ganciclovir’s antiviral activity inhibits virus replication. This inhibitory action is highly selective as the drug must be converted to the active form by a virus-encoded cellular enzyme, thymidine kinase (TK) . TK catalyzes phosphorylation of ganciclovir to the monophosphate, which is then subsequently converted into the diphosphate by cellular guanylate kinase and into the triphosphate by a number of cellular enzymes.
Description of the Drug: Ganciclovir is a DNA polymerase inhibitor used to treat cytomegalovirus and herpetic keratitis of the eye.
Protein Data Bank:
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB01004