Furosemide

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Scientific Name: Furosemide
Brand Name: Furoscix, Lasix
Company Owner: Abraxis pharmaceutical products, App pharmaceuticals llc, Astrazeneca lp, Baxter healthcare corp anesthesia and critical care, Hospira inc, International medication system, Luitpold pharmaceuticals inc, Marsam pharmaceuticals llc, Organon usa inc, Smith and nephew solopak div smith and nephew, Warner chilcott div warner lambert co, Watson laboratories inc, Wockhardt ltd, Wyeth ayerst laboratories, Sanofi aventis us llc, Roxane laboratories inc, Wockhardt eu operations (swiss) ag, Dava pharmaceuticals inc, Excellium pharmaceutical inc, International medication systems ltd, Ipca laboratories ltd, Ivax pharmaceuticals inc sub teva pharmaceuticals usa, Kalapharm inc, Mutual pharmaceutical co inc, Mylan pharmaceuticals inc, Sandoz inc, Superpharm corp, Vintage pharmaceuticals inc, County line pharmaceuticals llc
Mechanism Of Action Furosemide promotes diuresis by blocking tubular reabsorption of sodium and chloride in the proximal and distal tubules, as well as in the thick ascending loop of Henle. This diuretic effect is achieved through the competitive inhibition of sodium-potassium-chloride cotransporters (NKCC2) expressed along these tubules in the nephron, preventing the transport of sodium ions from the lumenal side into the basolateral side for reabsorption. This inhibition results in increased excretion of water along with sodium, chloride, magnesium, calcium, hydrogen, and potassium ions.
Description of the Drug: Furosemide is a loop diuretic used to treat hypertension and edema in congestive heart failure, liver cirrhosis, renal disease, and hypertension.
Protein Data Bank:
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB00695