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Scientific Name: Fulvestrant
Brand Name: Faslodex
Company Owner: Astrazeneca pharmaceuticals lp
Mechanism Of Action Fulvestrant competitively and reversibly binds to estrogen receptors present in cancer cells and achieves its anti-estrogen effects through two separate mechanisms. First, fulvestrant binds to the receptors and downregulates them so that estrogen is no longer able to bind to these receptors. Second, fulvestrant degrades the estrogen receptors to which it is bound. Both of these mechanisms inhibit the growth of tamoxifen-resistant as well as estrogen-sensitive human breast cancer cell lines.
Description of the Drug: Fulvestrant is an estrogen receptor antagonist used to treat HR+ breast cancer that may also be HER2-.
Protein Data Bank: Not Available
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB00947