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Scientific Name: Fosfomycin
Brand Name: Monurol
Company Owner: Zambon spa italy
Mechanism Of Action Fosfomycin exerts its bactericidal effects by binding covalently to a cysteine in the active site of the UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) enzyme, rendering it inactive. By preventing MurA from catalyzing the condensation of phosphoenolpyruvate (PEP) with UDP-N-acetylglucosamine (UNAG) , fosfomycin inhibits the production of the peptidoglycan precursor UDP N-acetylmuramic acid (UDP-MurNAc) .
Description of the Drug: Fosfomycin is a broad spectrum antibiotic used to treat uncomplicated urinary tract infections.
Protein Data Bank:
Source: DrugBank Online – Retrieved 2023-01-23 from