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Scientific Name: Fondaparinux
Brand Name: Arixtra
Company Owner: Glaxosmithkline
Mechanism Of Action The antithrombotic activity of fondaparinux is the result of ATIII-mediated selective inhibition of Factor Xa. By selectively binding to ATIII, Fondaparinux potentiates (about 300 times) the neutralization of Factor Xa by ATIII. Neutralization of Factor Xa interrupts the blood coagulation cascade and thus inhibits thrombin formation and thrombus development. It is thought that fondaparinux is unlikely to induce thrombocytopenia via a heparin-induced thrombocytopenia (HIT) -like mechanism given its chemical structure
Description of the Drug: Fondaparinux is an anticoagulant used to prevent venous thromboembolism, to treat deep vein thrombosis, and to improve survival following myocardial infarction.
Protein Data Bank:
Source: DrugBank Online – Retrieved 2023-01-23 from