Fluorouracil

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Scientific Name: Fluorouracil
Brand Name: Actikerall, Carac, Efudex, Fluoroplex, Tolak
Company Owner: Sanofi aventis us llc, Valeant pharmaceuticals international, Allergan herbert skin care div allergan inc, Spear pharmaceuticals inc, Taro pharmaceutical industries ltd, Pharmacia and upjohn co, Teva parenteral medicines inc, Abic ltd, Abraxis pharmaceutical products, App pharmaceuticals llc, Bedford laboratories div ben venue laboratories inc, Bioniche pharma usa llc, Ebewe pharma ges mbh nfg kg, Marchar laboratories inc ltd, Smith and nephew solopak div smith and nephew, Watson laboratories inc, Elorac inc, Taro pharmaceuticals usa inc
Mechanism Of Action The precise mechanism of action has not been fully determined, but the main mechanism of fluorouracil is thought to be the binding of the deoxyribonucleotide of the drug (FdUMP) and the folate cofactor, N5–10-methylenetetrahydrofolate, to thymidylate synthase (TS) to form a covalently bound ternary complex. This results in the inhibition of the formation of thymidylate from uracil, which leads to the inhibition of DNA and RNA synthesis and cell death. Fluorouracil can also be incorporated into RNA in place of uridine triphosphate (UTP) , producing a fraudulent RNA and interfering with RNA processing and protein synthesis.
Description of the Drug: Fluorouracil is a pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment.
Protein Data Bank:
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB00544