Fludarabine
Back to search| Scientific Name: | Fludarabine |
| Brand Name: | Fludara |
| Company Owner: | Not Available |
| Mechanism Of Action | Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite appears to act by inhibiting DNA polymerase alpha, ribonucleotide reductase and DNA primase, thus inhibiting DNA synthesis. The mechanism of action of this antimetabolite is not completely characterized and may be multi-faceted. |
| Description of the Drug: | Fludarabine is a purine analog antimetabolite that inhibits DNA synthesis. |
| Protein Data Bank: | Not Available |
Source: DrugBank Online – DrugBank.com. Retrieved 2023-01-23 from https://go.drugbank.com/drugs/DB01073
